Preferential Brain Homing following Intranasal Administration of Trypanosoma cruzi
نویسندگان
چکیده
منابع مشابه
Preferential brain homing following intranasal administration of Trypanosoma cruzi.
The Chagas' disease parasite Trypanosoma cruzi commonly infects humans through skin abrasions or mucosa from reduviid bug excreta. Yet most studies on animal models start with subcutaneous or intraperitoneal injections, a distant approximation of the skin abrasion route. We show here that atraumatic placement of T. cruzi in the mouse nasal cavity produced low parasitemia, high survival rates, a...
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Manganese chloride (50-800 micrograms) was injected unilaterally into the right nostril of rats and its accumulation in the central nervous system (CNS) was monitored. Brain manganese levels were elevated in a dose-dependent, time-dependent, and tissue-dependent manner. Elevated levels of manganese were detected in the right olfactory bulb and olfactory tubercle within 12 hr after instillation ...
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The anti-Trypanosoma cruzi activity of extracts from 13 Argentinean Asteraceae species was determined. Dichloromethane and methanol extracts of Acmella bellidioides, Aspilia silphioides, Viguiera tuberosa, Calyptocarpus biaristatus, Hyalis argentea, Helenium radiatum, Gaillardia megapotamica, Verbesina subcordata, Gymnocoronis spilanthoides, Viguiera anchusaefolia, Thelesperma megapotamicum, Ze...
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The anti-Trypanosoma cruzi activity of extracts from 13 Argentinean Asteraceae species was determined. Dichloromethane and methanol extracts of Acmella bellidioides, Aspilia silphioides, Viguiera tuberosa, Calyptocarpus biaristatus, Hyalis argentea, Helenium radiatum, Gaillardia megapotamica, Verbesina subcordata, Gymnocoronis spilanthoides, Viguiera anchusaefolia, Thelesperma megapotamicum, Ze...
متن کاملElectrocardiogram Assessment in Chough (Pyrrhocorax pyrrhocorax) Following Intranasal Administration of Anesthetics
Objective- The objective of the present study was to define electrocardiographic data following intranasal administration of diazepam, midazolam and xylazine with or without Ketamine in Chough. Design- To determine the heart effects of anesthetics in intranasal administration, an experimental in vivo study was employed. Animals- Ten healthy Choughs were examined in the current study...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2009
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.01434-08